TRAF3 抗体
Quick Overview for TRAF3 抗体 (ABIN5700977)
抗原
See all TRAF3 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- TRAF3 antibody
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免疫原
- TNF receptor-associated factor 3
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- TRAF3 (TNF Receptor-Associated Factor 3 (TRAF3))
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别名
- TRAF3
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背景
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Synonyms: TNF receptor-associated factor 3|CD40 receptor-associated factor 1 (CRAF1)|CD40-binding protein (CD40BP)|LMP1-associated protein 1 (LAP1)|RING-type E3 ubiquitin transferase TRAF3|TRAF3|CAP-1|CRAF1|TRAFAMN
Background: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
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基因ID
- 7187
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UniProt
- Q13114
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途径
- NF-kappaB Signaling, Apoptosis, TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
抗原
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